| 鲁谨菡,刘润乐,曹艳珍,刘雨,白燕玲.化学通报,2025,88(6):588-597,587. |
| 近红外二区硫化氢与谷胱甘肽探针的研究进展 |
| Research Progress of Hydrogen Sulfide and Glutathione Probes in the Near-Infrared Second Region |
| 投稿时间：2024-12-04 修订日期：2025-02-26 |
| DOI： |
| 中文关键词: 近红外二区 荧光探针 硫化氢 谷胱甘肽 |
| 英文关键词:Near-Infrared Second Region, Fluorescent Probe, Hydrogen Sulfide, Glutathione |
| 基金项目:国家自然科学基金项目(82202240)、泰山学者青年专家工程项目(tsqn202211249)、山东省高等学校“青创科技支持计划”项目(2021KJ098)和齐鲁理工学院人才科研项目(QIT22TP001)资助 |
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| 摘要点击次数: 398 |
| 全文下载次数: 192 |
| 中文摘要: |
| 硫化氢(H2S)是继一氧化氮和一氧化碳之后的第三大气体信号分子,不仅参与调节血管舒张、神经传导和细胞凋亡等生理过程,还可作为癌症的生物标志物。谷胱甘肽(GSH)作为一种重要的生物抗氧化剂,在细胞中发挥着关键的生理功能,其浓度变化与多种疾病的发生密切相关。传统的检测方法如色谱法、酶联免疫吸附法等,虽然能在一定程度上满足需要,但存在操作复杂、灵敏度不够等缺陷。因此,开发高灵敏度、高选择性的检测方法对于了解其生理病理过程、揭示疾病发生机制、发展新的治疗策略具有重要意义。近年来,近红外二区(NIR-II)荧光探针因其优越的光学性能而受到广泛关注。该类探针在生物组织中的穿透深度大,自发荧光干扰小,提高了检测的灵敏度和准确性。综述了NIR-II 荧光探针在H2S和GSH的检测及其生物成像中的应用。 |
| 英文摘要: |
| Hydrogen sulfide (H2S) is the third gaseous signaling molecule after nitric oxide (NO) and carbon monoxide (CO). It is not only involved in regulating physiological processes such as vasodilation, nerve conduction and cell apoptosis, but also used as a biomarker for cancer. Glutathione (GSH), as an important biological antioxidant, plays a key physiological function in cells, and changes in its concentration are closely related to the occurrence of many diseases. Traditional detection methods such as chromatography and enzyme-linked immunosorbent assay, can meet the needs to a certain extent, but often have defects such as complex operation, long time and insufficient sensitivity. Although traditional detection methods such as chromatography and enzyme-linked immunosorbent assay can meet the needs to a certain extent, they have defects such as complex operation and insufficient sensitivity. Therefore, the development of highly sensitive and highly selective detection methods is of great significance for understanding its physiological and pathological processes, revealing the mechanism of disease occurrence, and developing new treatment strategies. In recent years, near-infrared second region (NIR-II) fluorescent probes have attracted widespread attention due to their superior optical properties. These probes have a large penetration depth in biological tissues and has low autofluorescence interference, which greatly improves the sensitivity and accuracy of detection. This paper reviews the application of NIR-II fluorescent probes in the detection of H2S and GSH and their biological imaging. |
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