| Mitochondria, as crucial organelles within eukaryotic cells, play a decisive role in processes such as cell homeostasis, signal transduction, immunity, and metabolism. Not only are mitochondria the principal energy source of cells, but they also engage in the regulation of significant physiological and disease-related processes. Research on the mechanisms of biological reactions such as substance metabolism, stress response, and cellular senescence at the mitochondrial level can furnish effective and detailed insights into the pathogenesis of relevant diseases, thereby providing guidance for early diagnosis and treatment. This article elaborates on mitochondrial-targeted fluorescent probes from the perspective of diverse fluorophores and expounds on the reaction mechanisms, fluorescence spectral responses, and their applications in cell imaging. Such probes can accurately target mitochondria and realize the visual monitoring of related biomolecules or microenvironments.Mitochondrial-targeted fluorescent probes primarily detect substances such as reactive oxygen species (ROS) and reactive sulfur species (RSS). These probes can distinguish cancer cells from normal cells in biological systems based on the differences in mitochondrial polarity,thus providing a valuable tool for the early diagnosis of various diseases including cancer. |
京公网安备11010802047317号